About ConcePTION

ConcePTION is a project funded by the Innovative Medicines Initiative, a private public partnership. The project was launched in April 2019.

We believe that we have an important societal obligation to radically and rapidly reduce uncertainty about the effects of medication used during pregnancy and breastfeeding to benefit women in making informed decisions about medications used before, during and after pregnancy.


To be able to say that it is safe for a pregnant woman to take a particular medicine, we need to know that the safety data is robust. The ConcePTION project is piecing European data together, building a system to generate evidence on medicine safety for pregnant and breastfeeding women. A recent report provides an inventory of the core elements that are needed to generate the evidence that is required. The report guides researchers in performing high quality and meaningful population-based studies: allowing women and their doctors to make informed decisions and weigh the benefits against the risks of treatments. | READ MORE >>
The ConcePTION project is committed to building safety evidence for women and their doctors. One of our first contributions is a systematic review and meta-analysis of pregnancy and fetal outcomes in women with Multiple sclerosis (also known as MS). The results add to the existing evidence for women with MS considering pregnancy and for neurologists deciding on treatment during pregnancy and counselling women with unplanned pregnancies. The meta-analysis also highlights the need for more studies to address the lack of evidence. The authors are currently performing further studies within IMI ConcePTION to address some of these knowledge gaps.  | READ MORE >>
Breastfeeding offers health and wellbeing benefits for both mother and child. Half of new mothers need medicines. Many medicines are likely to be safe, but human lactation studies are challenging to conduct. As a result, women often have to choose between continuing their medical treatment and breastfeeding their infant. In a recent Biomedicine & Pharmacotherapy publication, ConcePTION researchers provide an extensive overview of non-clinical and computational methods that can be used to inform human lactation studies. And how these methods can be combined to enable prediction of medicine transfer into breast milk when human lactation studies cannot be performed. | READ MORE >>

The ConcePTION consortium

The project unites an unprecedented 88 organizations from 22 countries, including the European Medicines Agency, drug manufacturers, academia, public health organizations, and teratology networks to innovate new solutions to a decades-long public health issue.


The ConcePTION project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 821520. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.